Tauro-beta-muricholic Acid (sodium salt)

Tauro-beta-muricholic acid (TbetaMCA) is a competitive and reversible antagonist of the farnesoid X receptor (FXR, IC50 = 40 µM) and a taurine-conjugated form of the murine-specific primary bile acid beta-muricholic acid (Cay-20287). TbetaMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor. TbetaMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.Formal Name: 2-[[(3alpha,5beta,6beta,7beta)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt. CAS Number: 145022-92-0. Synonyms: Tauro-beta-muricholate, TbetaMCA. Molecular Formula: C26H44NO7S . Na. Formula Weight: 537.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.1 mg/ml, Ethanol: 1 mg/ml. SMILES: C[C@H](CCC(NCCS([O-])(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]. InChi Code: InChI=1S/C26H45NO7S.Na/c1-15(4-7-21(29)27-12-13-35(32,33)34)17-5-6-18-22-19(9-11-25(17,18)2)26(3)10-8-16(28)14-20(26)23(30)24(22)31,/h15-20,22-24,28,30-31H,4-14H2,1-3H3,(H,27,29)(H,32,33,34),/q,+1/p-1/t15-,16-,17-,18+,19+,20+,22+,23+,24-,25-,26-,/m1./s1. InChi Key: NYXROOLWUZIWRB-GPHZYVDLSA-M.