Zu "K08537" wurden 80 Artikel gefunden!
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Tauro-beta-muricholic Acid (sodium salt)
Artikelnummer: Cay20289-1
Tauro-beta-muricholic acid (TbetaMCA) is a competitive and reversible antagonist of the farnesoid X receptor (FXR, IC50 = 40 µM) and a taurine-conjugated form of the murine-specific primary bile acid beta-muricholic acid (Cay-20287). TbetaMCA accumulates in germ-free mice under normal conditions but is reduced after...
| Schlagworte: | Tauro-beta-muricholate, TbetaMCA, 2-[[(3alpha,5beta,6beta,7beta)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic... |
| Anwendung: | FXR antagonist |
| CAS | 145022-92-0 |
| MW: | 537.7 D |
ab 116,00 €
Tauro-alpha-muricholic Acid (sodium salt)
Artikelnummer: Cay20288-1
Tauro-alpha-muricholic acid (TalphaMCA) is an antagonist of the farnesoid X receptor (FXR, IC50 = 28 µM) and a taurine-conjugated form of the murine-specific primary bile acid alpha-muricholic acid (Cay-20291). TalphaMCA is common in rodents but has also been found in small amounts in human serum.Formal Name:...
| Schlagworte: | Tauro-alpha-muricholate, TalphaMCA,... |
| Anwendung: | Farnesoid X receptor (FXR) antagonist |
| CAS | 2260905-08-4 |
| MW: | 537.7 D |
260,00 €
Chenodeoxycholic Acid
Artikelnummer: Cay10011286-1
Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid. It is formed from cholesterol in the liver via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. CDCA is a farnesoid X receptor (FXR) agonist that binds to FXRs in a TR-FRET assay (EC50 = 13 µM) and...
| Schlagworte: | Anthropodeoxycholic Acid, CDCA, Fluibil, Hekbilin, Kebilis, Ulmenide, (3alpha,5beta,7alpha)-3,7-dihydroxy-cholan-24-oic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 474-25-9 |
| MW: | 392.6 D |
ab 49,00 €
6-ECDCA
Artikelnummer: AG-CR1-3560-M005
Potent and selective farnesoid X receptor FXR agonist (EC50= 99nM) [1]. Induces SHP in HSCs to suppress TIMP-1 expression [2]. Apoptosis inducer [2]. Protects against liver fibrosis development in rat in vivo [2]. Displays anticholeretic activity in rat in vivo [3]. Promotes preadipocyte differentiation [4]....
| Schlagworte: | 6alpha-Ethyl-chenodeoxycholic acid, 6-alpha-ECDC, Obeticholic acid, INT-747, OCA |
| Anwendung: | FXR agonist |
| CAS | 459789-99-2 |
| MW: | 420,3 D |
ab 22,00 €
GW 4064
Artikelnummer: Cay10006611-5
Farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity. GW 4064 is a selective agonist of FXR (EC50 = 15 nM). It displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 µM. GW...
| Schlagworte: | 3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-benzoic acid |
| Anwendung: | FXR agonist |
| CAS | 278779-30-9 |
| MW: | 542.8 D |
ab 49,00 €
Chenodeoxycholic Acid-d4
Artikelnummer: Cay20848-1
Chenodeoxycholic acid-d4 (CDCA-d4) is intended for use as an internal standard for the quantification of CDCA (Cay-10011286) by GC- or LC-MS. CDCA is a hydrophobic primary bile acid. It is formed from cholesterol in the liver via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and...
| Schlagworte: | CDCA-d4, 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic-2,2,4,4-d4 acid |
| Anwendung: | GC-MS, LC-MS, internal standard, CDCA quantification |
| CAS | 99102-69-9 |
| MW: | 396.6 D |
ab 67,00 €
Glycine-beta-muricholic Acid
Artikelnummer: Cay9003230-10
Glycine-beta-muricholic acid (GbetaMCA) is an intestine-selective antagonist of the farnesoid X receptor (FXR) and the glycine-conjugated form of the murine-specific primary bile acid beta-muricholic acid (Cay-20287). It inhibits expression of the FXR target genes Shp and Fgf15 induced by the FXR ligands...
| Schlagworte: | Gly-MCA, GbetaMCA, N-[(3alpha,5beta,6beta,7beta)-3,6,7-trihydroxy-24-oxocholan-24-yl]-glycine |
| Anwendung: | FXR antagonist |
| CAS | 66225-78-3 |
| MW: | 465.6 D |
ab 174,00 €
Stigmasterol
Artikelnummer: AG-CN2-0412-G001
White to off-white solid. Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water. Anti-hypercholestrolemic compound, Anti-inflammatory and immune-modulating effects, Anticancer compound. Chemopreventive, Cytostatic. Cell growth inhibitor, Antimutagenic, Potent in vitro antagonist of FXR (farnesoid...
| Schlagworte: | Stigmasterin, Phytosterol, beta-Stigmasterol, Serposterol, Wulzen anti-stiffness Factor, NSC8095 |
| Anwendung: | Chemopreventive compound |
| CAS | 83-48-7 |
| MW: | 412,7 D |
ab 44,00 €
Tauro-beta-muricholic Acid-d4 (sodium salt)
Artikelnummer: Cay27040-1
Tauro-beta-muricholic acid-d4 (TbetaMCA-d4) is intended for use as an internal standard for the quantification of TbetaMCA (Cay-20289) by GC- or LC-MS. TbetaMCA is a competitive and reversible antagonist of the farnesoid X receptor (FXR, IC50 = 40 µM) and a taurine-conjugated form of the murine-specific primary bile...
| Schlagworte: | Tauro-beta-muricholate-d4, TbetaMCA-d4,... |
| Anwendung: | Internal standard, quantification, FXR antagonist |
| MW: | 541.7 D |
943,00 €
FXR (human) Reporter Assay Kit
Artikelnummer: IB-IB00601-32
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human farnesoid X receptor (NR1H4), a ligand-dependent transcription factor commonly referred to as FXR. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | BAR, NR1H4, Bile acid receptor, Farnesol receptor HRR-1, RXR-interacting protein 14, Farnesoid X-activated receptor,... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
Tauro-alpha-muricholic Acid-d4 (sodium salt)
Artikelnummer: Cay27039-1
Tauro-alpha-muricholic acid-d4 (TalphaMCA-d4) is intended for use as an internal standard for the quantification of TalphaMCA (Cay-20288) by GC- or LC-MS. TalphaMCA is an antagonist of the farnesoid X receptor (FXR, IC50 = 28 µM) and a taurine-conjugated form of the murine-specific primary bile acid alpha-muricholic...
| Schlagworte: | Tauro-alpha-muricholate-d4, TaMCA-d4,... |
| Anwendung: | Internal standard, quantification, FXR antagonist |
| MW: | 541.7 D |
ab 498,00 €
XL335
Artikelnummer: Cay23350-5
XL335 is an orally bioavailable and potent agonist of the farnesoid X receptor (FXR) with an EC50 value of 4 nM in CV-1 cells transfected with human FXR. It is selective for FXR over a panel of 15 nuclear receptors at concentrations up to 10 µM. XL335 induces expression of mouse intestinal bile acid binding protein...
| Schlagworte: | FXR 450, Turofexorate Isopropyl, WAY-362450,... |
| Anwendung: | FXR agonist |
| CAS | 629664-81-9 |
| MW: | 438.5 D |
ab 145,00 €