Taraxasterol

Taraxasterol is a pentacyclic triterpene that has been found in T. mongolicum and has diverse biological activities. It decreases LPS-induced increases in the secreted levels of nitrite, prostaglandin E2 (PGE2, Cay-14010), TNF-alpha, IL-1beta, and IL-6 from RAW 264.7 macrophages when used at concentrations of 5 and 12.5 µg/ml. Taraxasterol reduces the levels of hepatitis B virus (HBV) surface antigen (HBsAg), HBV e antigen (HBeAg), and HBV DNA secreted from HBV-infected HepG2 2.2.15 hepatocytes in a concentration-dependent manner. In vivo, taraxasterol (10 mg/kg per day) prevents increases in liver damage, hepatocyte apoptosis, serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST), and hepatic levels of malondialdehyde (MDA), as well as decreases in the hepatic levels of glutathione (GSH), superoxide dismutase (SOD), and Bax in a mouse model of liver injury induced by the plant lectin concanavalin A (Cay-14951).Formal Name: (3beta,18alpha,19alpha)-urs-20(30)-en-3-ol. CAS Number: 1059-14-9. Molecular Formula: C30H50O. Formula Weight: 426.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Soluble. SMILES: C[C@]12[C@]3([C@@](CC[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC2)C)([H])[C@]5([H])[C@@](CC3)(CCC([C@H]5C)=C)C)C. InChi Code: InChI=1S/C30H50O/c1-19-11-14-27(5)17-18-29(7)21(25(27)20(19)2)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21-,22+,23-,24+,25-,27-,28+,29-,30-/m1/s1. InChi Key: XWMMEBCFHUKHEX-ZJJHUPNDSA-N.