Sphingosine-d7 (d18:1)

Sphingosine-d7 (d18:1) is intended for use as an internal standard for the quantification of sphingosine (d18:1) (Cay-10007907) by GC- or LC-MS. Sphingosine (d18:1) is formed primarily from the breakdown of ceramide. Sphingosine (d18:1) inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase. Phosphorylation of sphingosine (d18:1) by sphingosine kinases 1 and 2 (SPHK1, SPHK2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.Formal Name: (2S,3R,4E)-2-amino-4-octadecene-16,16,17,17,18,18,18-d7-1,3-diol. CAS Number: 1246304-34-6. Synonyms: (-)-Sphingosine-d7, D-erythro-Sphingosine C-18-d7. Molecular Formula: C18H30D7NO2. Formula Weight: 306.5. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 2 mg/ml, Ethanol: miscible. SMILES: OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]. InChi Code: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1/i1D3,2D2,3D2. InChi Key: WWUZIQQURGPMPG-AVMMVCTPSA-N.