Simvastatin Hydroxy Acid (ammonium salt)

Simvastatin hydroxy acid is an inhibitor of HMG-CoA reductase (Ki = 0.12 nM) and an active metabolite of simvastatin (Cay-10010344, Cay-10010345). It is formed from simvastatin via hydrolysis and nonspecific esterases.Formal Name: (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid, monoammonium salt. CAS Number: 139893-43-9. Synonyms: SVA Hydroxy Acid. Molecular Formula: C25H39O6 . NH4. Formula Weight: 453.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 231, 238, 247 nm. SMILES: CCC(C)(C)C(O[C@@H]1[C@@]2([H])C(C=C[C@@H]([C@@H]2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C)=C[C@@H](C1)C)=O.[NH4+]. InChi Code: InChI=1S/C25H40O6.H3N/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29,/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29),1H3/t15-,16-,18+,19+,20-,21-,23-,/m0./s1. InChi Key: FFPDWNBTEIXJJF-OKDJMAGBSA-N.