Zu "K00021" wurden 123 Artikel gefunden!
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Anti-Recombinant HMGCR, clone A254
Artikelnummer: E-AN301555L.100
3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a transmembrane glycoprotein of the endoplasmic reticulum. It is the rate-limiting enzyme for cholesterol biosynthesis and non-sterol isoprenoid biosynthesis. Play a key role in cellular cholesterol homeostasis. The activity of HMGCR is regulated by negative...
| Schlagworte: | Anti-HMGCR, Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase, Recombinant HMGCR Monoclonal Antibody |
| Anwendung: | WB, IF, FCM, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 304,00 €
Rosuvastatin (sodium salt)
Artikelnummer: Cay44550-100
Rosuvastatin is an inhibitor of HMG-CoA reductase (IC50 = 5 nM). It inhibits cholesterol synthesis in isolated rat hepatocytes with an IC50 value of 0.16 nM. Rosuvastatin (10 mg/kg) reduces plasma total cholesterol, triglyceride, LDL-C, and oxidized LDL-C levels in Ldlr-/- mice fed a high-fat diet. It decreases the...
| Schlagworte: | ZD 4522,... |
| Anwendung: | HMG-CoA reductase inhibitor |
| CAS | 147098-18-8 |
| MW: | 503,52 D |
ab 73,00 €
Simvastatin
Artikelnummer: LKT-S3449.500
A potent HMG-CoA reductase inhibitor and hypocholesterolemic agent. Inhibits cell proliferation of human glioma cells and of acute myeloid leukemia cells. Anti-carcinogenic during the promotion phase of radiation-induced mammary tumors.
| Anwendung: | HMG-CoA reductase inhibitor |
| CAS | 79902-63-9 |
| MW: | 418,57 D |
ab 90,00 €
Rosuvastatin Calcium
Artikelnummer: LKT-R5974.25
Statin, HMG-CoA reductase inhibitor, potential NADPH oxidase and PKC inhibitor.
| Schlagworte: | (S-((R*,S*-(E)))- 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2- (methyl(methylsulfonyl) amino)-5-pyrimidinyl)-3,5-dihydroxy-... |
| Anwendung: | HMGCoA reductase inhibitor |
| CAS | 147098-20-2 |
| MW: | 1001,14 D |
ab 234,00 €
Lovastatin
Artikelnummer: Cay10010338-50
| Schlagworte: | (+)-Mevinolin, Monacolin K, NSC 633781, 2S-methyl-butanoic acid,... |
| Anwendung: | NF-kappaB activation inhibitor |
| CAS | 75330-75-5 |
| MW: | 404.5 D |
ab 38,00 €
Simvastatin
Artikelnummer: Cay10010344-5
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
| Schlagworte: | MK-733,... |
| Anwendung: | HMG-CoA reductase inhibitor |
| CAS | 79902-63-9 |
| MW: | 418.6 D |
ab 38,00 €
Fluvastatin
Artikelnummer: Cay10010334-10
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
| Schlagworte: | 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid |
| Anwendung: | HMG-CoA reductase inhibitor |
| CAS | 93957-54-1 |
| MW: | 411.5 D |
ab 60,00 €
Atorvastatin (calcium salt hydrate)
Artikelnummer: Cay10493-50
Atorvastatin is an inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol synthesis, that has IC50 values of 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively. Formulations containing atorvastatin have been used in the treatment of...
| Schlagworte: | 2-(4-fluorophenyl)-betaR,deltaR-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic... |
| Anwendung: | HMGCR inhibitor |
| CAS | 357164-38-6 |
| MW: | 577.7 D |
ab 49,00 €
Mevinolin
Artikelnummer: LKT-M1687.50
Statin, naturally produced by mushrooms, HMG-CoA reductase inhibitor.
| Schlagworte: | Mevacor, MK-803, Lovalip, Mevinacor, Mevlor, Sivlor, Lovastatin, (2S)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,-... |
| Anwendung: | HMG-CoA reductase inhibitor |
| CAS | 75330-75-5 |
| MW: | 404,54 D |
ab 173,00 €
SR-12813
Artikelnummer: Cay18115-10
SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity by enhancing the degradation of HMG-CoA reductase in various animal models. SR-12813 is also a high affinity ligand for human and rabbit pregnane X receptors (Kd = 41 nM, EC50 = 137 nM for hPXR in vitro) and can induce cytochrome P450...
| Schlagworte: | GW 485801, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid P,P,P',P'-tetraethyl ester |
| Anwendung: | HMG-CoA reductase degradation enhancer, pregnane X receptor ligand |
| CAS | 126411-39-0 |
| MW: | 504.5 D |
ab 128,00 €
Simvastatin-d6
Artikelnummer: Cay22181-1
Simvastatin-d6 is intended for use as an internal standard for the quantification of simvastatin (Cay-10010344, Cay-10010345) by GC- or LC-MS. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2...
| Schlagworte: | 2,2-di(methyl-d3)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-... |
| Anwendung: | GC-MS, LC-MS, internal standard, HMG-CoA reductase inhibitor |
| CAS | 1002347-71-8 |
| MW: | 424.6 D |
ab 133,00 €
Fluvastatin sodium
Artikelnummer: LKT-F4482.10
An anticholesterol agent. It is a HMG-CoA reductase inhibitor and antioxidant.
| Schlagworte: | Fluindostatin, XU-62-320 |
| Anwendung: | HMG-CoA reductase inhibitor |
| CAS | 93957-55-2 |
| MW: | 433,45 D |
ab 71,00 €