PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl) (sodium salt)

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin alpha and Akts are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC. Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references and .Formal Name: 1-(1-octadecanoyl-2R-(5Z,8Z,11Z,14Z)-eicosatetraenoylphosphatidyl)inositol-3,4,5-trisphosphate, tetrasodium salt. Synonyms: PI(3,4,5)P3, PI(3,4,5)P3 (18:0/20:4), PI(P-18:0/20:4), PIP3[3,4,5](18:0/20:4), PIP3[3',4',5'](18:0/20:4), Phosphatidylinositol-3,4,5-triphosphate C-18 (sodium salt), SAPI-3,4,5-P3. Molecular Formula: C47H82O22P4 . 4Na. Formula Weight: 1215.0. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. Solubility: CHCl3:CH3OH:H2O (3:2:1): 10 mg/ml, PBS (pH 7.2): Freely soluble. SMILES: CCCCCCCCCCCCCCCCCC(OCC(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COP([O-])(O[C@@H]1[C@H](O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@H]1O)=O)=O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C47H86O22P4.4Na/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)65-39(37-63-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2)38-64-73(61,62)69-44-42(50)45(66-70(52,53)54)47(68-72(58,59)60)46(43(44)51)67-71(55,56)57,,,,/h11,13,. InChi Key: JCZJAQPLXIVRFT-BPEMJPOJSA-J. Side Chain Carbon Sum: 38:4.