Perifosine

Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5 µM at 24 h) and is associated with rapidly decreased Akt activation. In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.Formal Name: 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-piperidinium, inner salt. CAS Number: 157716-52-4. Molecular Formula: C25H52NO4P. Formula Weight: 461.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CCCCCCCCCCCCCCCCCCOP(OC1CC[N+](C)(C)CC1)([O-])=O. InChi Code: InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3. InChi Key: SZFPYBIJACMNJV-UHFFFAOYSA-N.