Perifosine

Perifosine is an alkylphospholipid analog that exhibits anticancer chemotherapeutic and anti-inflammatory activities. Perifosine directly inhibits Akt by binding at multiple sites. In macrophages, perifosine inhibits LPS-induced increases in TNF- and ERK activation and activates AMPK. In colorectal cancer, hepatocellular carcinoma, and multiple myeloma cells, perifosine induces apoptosis and inhibits growth, in clinical settings, perifosine enhances the anticancer activity of other chemotherapeutics.