Oxysophocarpine

Oxysophocarpine is an alkaloid that has been found in S. flavescens and has diverse biological activities, including neuroprotective, anticancer, anti-inflammatory, and analgesic properties. It increases cell survival and decreases lactate dehydrogenase (LDH) leakage and loss of mitochondrial membrane potential in rat primary hippocampal neurons in a model of oxygen-glucose deprivation and reperfusion injury when used at concentrations of 1, 2, and 5 µM. Oxysophocarpine (5 µM) inhibits proliferation and reduces migration and invasion of SCC-9 and SCC-15 oral squamous cell carcinoma (OSCC) cells in vitro. It reduces tumor growth in an SCC-9 mouse xenograft model when administered at a dose of 80 mg/kg. Oxysophocarpine (40 and 80 mg/kg) inhibits xylene-induced ear swelling and carrageenan-induced paw edema in mice. It also reduces carrageenan-induced decreases in the paw withdrawal threshold and prevents carrageenan-induced increases in paw tissue levels of TNF-alpha, IL-1beta, IL-6, and prostaglandin E2 (PGE2, Cay-14010) in mice when administered at a dose of 80 mg/kg.Formal Name: (4R,7aS,13aR,13bR,13cS)-2,3,6,7,7a,8,13,13a,13b,13c-decahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 4-oxide. CAS Number: 26904-64-3. Synonyms: (+)-Oxysophocarpine, Sophocarpine N-oxide. Molecular Formula: C15H22N2O2. Formula Weight: 262.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 262 nm. SMILES: [O-][N@+]1(CCC2)[C@]3([H])[C@@]2([H])[C@](CC=CC4=O)([H])N4C[C@]3([H])CCC1. InChi Code: InChI=1S/C15H22N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h1,7,11-13,15H,2-6,8-10H2/t11-,12+,13+,15-,17+/m0/s1. InChi Key: QMGGMESMCJCABO-JARXUMMXSA-N. Origin: Plant/Sophora flavescens Ait..