Nuciferine

Nuciferine is an alkaloid that has been found in N. nucifera and has diverse biological activities. It acts as a partial agonist at dopamine D2 receptors, as well as an inverse agonist at the serotonin receptor subtype 5-HT7, and an antagonist at the 5-HT2B and 5-HT2C receptors (EC50s = 65.07, 150, 478, and 131 nM, respectively). Nuciferine is also an antagonist at schistosome Sm.5-HTRL receptors (IC50 = 240 nM) and inhibits 5-HT-induced motility of larval and adult S. mansoni when used at a concentration of 10 µM. It activates PPARalpha, PPARbeta/delta, and PPARgamma transcriptional activity in reporter assays and inhibits IL-6 and TNF-alpha production induced by LPS in RAW 264.7 cells. It prevents ferroptotic cell death induced by the GPX4 inhibitor RSL3 in HK-2 and HEK293T cells when used at concentrations of 10, 20, and 40 µM and prevents lipid peroxidation in a mouse model of acute kidney injury. Dietary administration of nuciferine (15 mg/kg) reduces increases in serum triglyceride, total cholesterol, LDL, and free fatty acid levels, as well as markers of hepatic steatosis, in a mouse model of high-fat diet-induced hyperlipidemia.Formal Name: 5,6,6aR,7-tetrahydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline. CAS Number: 475-83-2. Synonyms: (-)-Nuciferine, Sanjoinine E, VLT 049. Molecular Formula: C19H21NO2. Formula Weight: 295.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: slightly soluble, Ethanol: 1 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 272 nm. SMILES: COC1=C2C3=C(C=C1OC)CCN(C)[C@]3([H])CC4=CC=CC=C42. InChi Code: InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1. InChi Key: ORJVQPIHKOARKV-OAHLLOKOSA-N. Origin: Plant/Nelumbo nucifera leaf.