Nuciferine

Nuciferine
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay33839-5 5 mg -

6 - 10 Werktage*

61,00 €
Cay33839-25 25 mg -

6 - 10 Werktage*

250,00 €
Cay33839-50 50 mg -

6 - 10 Werktage*

439,00 €
Cay33839-100 100 mg -

6 - 10 Werktage*

757,00 €
 
Nuciferine is an alkaloid that has been found in N. nucifera and has diverse biological... mehr
Produktinformationen "Nuciferine"
Nuciferine is an alkaloid that has been found in N. nucifera and has diverse biological activities. It acts as a partial agonist at dopamine D2 receptors, as well as an inverse agonist at the serotonin receptor subtype 5-HT7, and an antagonist at the 5-HT2B and 5-HT2C receptors (EC50s = 65.07, 150, 478, and 131 nM, respectively). Nuciferine is also an antagonist at schistosome Sm.5-HTRL receptors (IC50 = 240 nM) and inhibits 5-HT-induced motility of larval and adult S. mansoni when used at a concentration of 10 µM. It activates PPARalpha, PPARbeta/delta, and PPARgamma transcriptional activity in reporter assays and inhibits IL-6 and TNF-alpha production induced by LPS in RAW 264.7 cells. It prevents ferroptotic cell death induced by the GPX4 inhibitor RSL3 in HK-2 and HEK293T cells when used at concentrations of 10, 20, and 40 µM and prevents lipid peroxidation in a mouse model of acute kidney injury. Dietary administration of nuciferine (15 mg/kg) reduces increases in serum triglyceride, total cholesterol, LDL, and free fatty acid levels, as well as markers of hepatic steatosis, in a mouse model of high-fat diet-induced hyperlipidemia.Formal Name: 5,6,6aR,7-tetrahydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline. CAS Number: 475-83-2. Synonyms: (-)-Nuciferine, Sanjoinine E, VLT 049. Molecular Formula: C19H21NO2. Formula Weight: 295.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: slightly soluble, Ethanol: 1 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 272 nm. SMILES: COC1=C2C3=C(C=C1OC)CCN(C)[C@]3([H])CC4=CC=CC=C42. InChi Code: InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1. InChi Key: ORJVQPIHKOARKV-OAHLLOKOSA-N. Origin: Plant/Nelumbo nucifera leaf.
Schlagworte: (-)-Nuciferine, Sanjoinine E, VLT 049, 5,6,6aR,7-tetrahydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline
Hersteller: Cayman Chemical
Hersteller-Nr: 33839

Eigenschaften

Anwendung: Bioactive alkaloid
MW: 295.4 D
Formel: C19H21NO2
Reinheit: >98%
Format: Solid

Datenbank Information

CAS : 475-83-2| Passende Produkte
KEGG ID : K04145 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H301, H402
P-Sätze: P264, P270, P273, P321, P330, P301+P310, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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