N-Palmitoyl Dopamine

Several different fatty acyl dopamine analogs, such as N-arachidonoyl dopamine (NADA), N-oleoyl dopamine (ODA) and N-palmitoyl dopamine (PALDA), have been isolated and characterized from bovine brain. Structurally, PALDA is the amide of palmitic acid and dopamine and is therefore a "hybrid" analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. Unlike NADA and ODA, PALDA is nearly inactive as a vanilloid receptor 1 (VR1) ligand and fails to elicit hyperalgesic or nocifensive responses in vivo. However, PALDA exhibits an "entourage" effect at concentrations of 0.1-10 µM by potentiating the VR1-mediated effects of NADA and anandamide.Formal Name: N-[2-(3,4-dihydroxyphenyl)ethyl]-hexadecanamide. CAS Number: 136181-87-8. Synonyms: PALDA. Molecular Formula: C24H41NO3. Formula Weight: 391.6. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 204, 283 nm. SMILES: CCCCCCCCCCCCCCCC(=O)NCCc1ccc(O)c(O)c1. InChi Code: InChI=1S/C24H41NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(28)25-19-18-21-16-17-22(26)23(27)20-21/h16-17,20,26-27H,2-15,18-19H2,1H3,(H,25,28). InChi Key: TWJJFOWLTIEYFO-UHFFFAOYSA-N.