Mefenamic Acid-d4

Mefenamic acid-d4 is intended for use as an internal standard for the quantification of mefenamic acid (Cay-23650) by GC- or LC-MS. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor. It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats. It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC). Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.Formal Name: 6-[(2,3-dimethylphenyl)amino]-benzoic-2,3,4,5-d4 acid. CAS Number: 1216745-79-7. Synonyms: C.I. 473-d4. Molecular Formula: C15H11D4NO2. Formula Weight: 245.3. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, Methanol: Slightly soluble. SMILES: CC1=CC=CC(NC2=C([2H])C([2H])=C([2H])C([2H])=C2C(O)=O)=C1C. InChi Code: InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)/i3D,4D,7D,8D. InChi Key: HYYBABOKPJLUIN-KNIGXJNHSA-N.