Leukotriene B5

Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. It is a metabolite of eicosapentaenoic acid (EPA, Cay-90110, Cay-90110.1, Cay-21908) formed through the 5-lipoxygenase (5-LO) pathway. LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner. In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells. LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platelet aggregation 8-fold less, potently than LTB4 (Cay-20110).Formal Name: 5S,12R-dihydroxy-6Z,8E,10E,14Z,17Z-eicosapentaenoic acid. CAS Number: 80445-66-5. Synonyms: LTB5. Molecular Formula: C20H30O4. Formula Weight: 334.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: >50 mg/ml, DMSO: >50 mg/ml, Ethanol: >50 mg/ml, PBS pH 7.2: >1 mg/ml. lambdamax: 271 nm. SMILES: CC/C=C\C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O. InChi Code: InChI=1S/C20H30O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h3-4,6-11,14-15,18-19,21-22H,2,5,12-13,16-17H2,1H3,(H,23,24)/b4-3-,8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1. InChi Key: BISQPGCQOHLHQK-HDNPQISLSA-N.