L-erythro Sphingosine (d18:1)

L-erythro Sphingosine is a synthetic stereoisomer of sphingosine (d18:1) (Cay-10007907). It inhibits protein kinase C (PKC) in vitro (IC50 = 3.3 mol%) and superoxide generation induced by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) in neutrophils as well as reduces growth of CHO cells (IC50s = 1.3 and 2 µM, respectively). L-erythro Sphingosine also inhibits dephosphorylation of the tumor suppressor retinoblastoma gene product (pRb, EC50 = 5 µM) and growth of MOLT-4 acute lymphoblastic leukemia cells (IC50 = 3.7 µM). [Matreya, LLC. Catalog No. 1826]Formal Name: (2R,3S,4E)-2-amino-4-octadecene-1,3-diol. CAS Number: 6036-75-5. Synonyms: L-erythro Sphingosine, L-erythro-C18-Sphingosine. Molecular Formula: C18H37NO2. Formula Weight: 299.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble, DMSO: soluble, Ethanol: soluble. SMILES: OC[C@@H](N)[C@@H](O)/C=C/CCCCCCCCCCCCC. InChi Code: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m1/s1. InChi Key: WWUZIQQURGPMPG-MCXRAWCPSA-N.