Hyodeoxycholic Acid

Hyodeoxycholic acid (HDCA) is a secondary bile acid. It is produced from lithocholic acid (Cay-20253) by gut bacteria. Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet. Serum levels of HDCA are increased in patients with Crohn's disease or ulcerative colitis.Formal Name: (5beta)-3alpha,6alpha-dihydroxy-cholan-24-oic acid. CAS Number: 83-49-8. Synonyms: HDCA, alpha-Hyodeoxycholic Acid, NSC 60672. Molecular Formula: C24H40O4. Formula Weight: 392.6. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. SMILES: C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C. InChi Code: InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1. InChi Key: DGABKXLVXPYZII-SIBKNCMHSA-N.