Grifolic Acid

GPR120 (free fatty acid receptor 4/FFAR4) is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long-chain free fatty acids. It has been linked to the ability of fatty acids to produce anti-inflammatory effects and to acutely potentiate insulin secretion. Grifolic acid is a selective partial agonist of GPR120 that induces ERK activation and intracellular calcium responses in mouse enteroendocrine STC-1 cells that express GPR120 endogenously, but not those expressing GPR40.Formal Name: 2,4-dihydroxy-6-methyl-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-benzoic acid. CAS Number: 80557-12-6. Molecular Formula: C23H32O4. Formula Weight: 372.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100mg/mL. lambdamax: 221, 268, 303 nm. SMILES: OC1=C(C/C=C(CC/C=C(C)/CC/C=C(C)\C)\C)C(O)=CC(C)=C1C(O)=O. InChi Code: InChI=1S/C23H32O4/c1-15(2)8-6-9-16(3)10-7-11-17(4)12-13-19-20(24)14-18(5)21(22(19)25)23(26)27/h8,10,12,14,24-25H,6-7,9,11,13H2,1-5H3,(H,26,27)/b16-10+,17-12+. InChi Key: QPIZDZGIXDKCRC-JTCWOHKRSA-N.