Fluocinonide

Fluocinonide is a synthetic fluorinated corticosteroid that binds to the glucocorticoid receptor and has anti-inflammatory properties. It prevents inflammation and epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014). Fluocinonide inhibits tumor promotion and DNA synthesis in mouse epidermis when applied topically at a dose of 10 µg/0.2 ml. It also acts as an agonist at the smoothened (Smo) receptor with an EC50 value of 1,000 nM in a ligand displacement assay in cells overexpressing the Smo receptor. Formulations containing fluocinonide are used in the treatment of various skin conditions, including psoriasis and atopic dermatitis.Formal Name: 21-(acetyloxy)-6alpha,9-difluoro-11beta-hydroxy-16alpha,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione. CAS Number: 356-12-7. Synonyms: NSC 101791. Molecular Formula: C26H32F2O7. Formula Weight: 494.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.2 mg/ml. lambdamax: 237 nm. SMILES: O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@@]4(C(COC(C)=O)=O)OC(C)(C)O5)=C1. InChi Code: InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1. InChi Key: WJOHZNCJWYWUJD-IUGZLZTKSA-N.