Falcarinol

Falcarinol is a C17-polyacetylene produced by the Apiaceae family that has antimicrobial properties due to its inhibition of fatty acid biosynthesis. Falcarinol binds to the human recombinant cannabinoid (CB) receptors, CB1 and CB2, (Kis = 594 and 2,100 nM, respectively) in an [3H]anandamide displacement assay in HEK293 cells. It differentially modulates synaptic and extrasynaptic GABAA receptors in a recombinant HEK293 system. In vitro assays of ATPase activity demonstrate that falcarinol inhibits breast cancer resistance protein ATP-binding cassette sub-family G member 2 (ABCG2, IC50 = 79.3 µM), a drug efflux transporter and mediator of drug resistance. Falcarinol (6.88 µg/g feed) also inhibits aberrant crypt foci by 26.6% in azoxymethane-induced rats.Formal Name: 1,9Z-heptadecadiene-4,6-diyn-3R-ol. CAS Number: 21852-80-2. Molecular Formula: C17H24O. Formula Weight: 244.4. Purity: >60%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. SMILES: CCCCCCC/C=C\CC#CC#C[C@H](O)C=C. InChi Code: InChI=1S/C17H24O/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17(18)4-2/h4,10-11,17-18H,2-3,5-9,12H2,1H3/b11-10-/t17-/m1/s1. InChi Key: UGJAEDFOKNAMQD-QXPKXGMISA-N.