DLin-MC2-DMA

DLin-MC2-DMA is an ionizable cationic lipid (pKa = 5.64) that has been used in the formation of lipid nanoparticles (LNPs). LNPs containing DLin-MC2-DMA and encapsulating siRNA targeting mRNA encoding mouse coagulation Factor VII (FVII) reduce hepatic levels of FVII in mice (ED50 = 0.6 mg/kg).Formal Name: N,N-dimethyl-beta-alanine (10Z,13Z)-1-(9Z,12Z)-9,12-octadecadien-1-yl-10,13-nonadecadien-1-yl ester. CAS Number: 1221271-55-1. Synonyms: MC2. Molecular Formula: C42H77NO2. Formula Weight: 628.1. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Chloroform: Slightly soluble, Ethanol: 10 mg/ml, Methanol: Slightly soluble. SMILES: O=C(CCN(C)C)OC(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC. InChi Code: InChI=1S/C42H77NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-41(45-42(44)39-40-43(3)4)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,41H,5-12,17-18,23-40H2,1-4H3/b15-13-,16-14-,21-19-,22-20-. InChi Key: BAHNSDYHBUZBBI-KWXKLSQISA-N.