D-erythro/L-threo Lysosphingomyelin (d18:1)

D-erythro/L-threo Lysosphingomyelin (d18:1)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay31557-5 5 mg -

5 - 10 Werktage*

199,00 €
Cay31557-10 10 mg -

5 - 10 Werktage*

332,00 €
Cay31557-50 50 mg -

5 - 10 Werktage*

1.574,00 €
 
Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins. It... mehr
Produktinformationen "D-erythro/L-threo Lysosphingomyelin (d18:1)"
Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins. It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate (S1P, Cay-62570). D-erythro Lysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3 (EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors). It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50 = ~35 nM). Levels of D-erythro lysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B. L-threo lysosphingomyelin is also an S1P1-3 agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively). This product is a mixture of D-erythro and L-threo lysosphingomyelin. [Matreya, LLC. Catalog No. 1321] Formal Name: 2-[[[(2-amino-3-hydroxy-4-octadecen-1-yl)oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium, inner salt. CAS Number: 82970-80-7. Synonyms: D-erythro/L-threo Lyso SM(18:1), D-erythro/L-threo Sphingosine-1-Phosphocholine (d18:1), D-erythro/L-threo-Sphingosylphosphorylcholine. Molecular Formula: C23H49N2O5P. Formula Weight: 464.6. Purity: >98%. Formulation: A solid. SMILES: NC(COP(OCC[N+](C)(C)C)([O-])=O)C(O)/C=C/CCCCCCCCCCCCC. InChi Code: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+. InChi Key: JLVSPVFPBBFMBE-ISLYRVAYSA-N.
Schlagworte: D-erythro/L-threo Lyso SM(18:1), D-erythro/L-threo Sphingosine-1-Phosphocholine (d18:1), D-erythro/L-threo-Sphingosylphosphorylcholine, 2-[[[(2-amino-3-hydroxy-4-octadecen-1-yl)oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium, inner salt
Hersteller: Cayman Chemical
Hersteller-Nr: 31557

Eigenschaften

Anwendung: Bioactive sphingolipid mixture
MW: 464.6 D
Formel: C23H49N2O5P
Reinheit: >98%
Format: Solid

Datenbank Information

CAS : 82970-80-7| Finde Alternativen
KEGG ID : K04290 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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