CP 346,086

CP 346,086 is an inhibitor of microsomal triglyceride transfer protein (MTTP, IC50 = 2 nM). It inhibits apolipoprotein B (ApoB) and triglyceride secretion in HepG2 cells (IC50 = 2.6 nM for both). CP 346,086 (10 mg/kg) lowers plasma triglyceride levels, as well as plasma total, VLDL, and LDL cholesterol levels in rats.Formal Name: N-[1,2,3,4-tetrahydro-2-(1H-1,2,4-triazol-5-ylmethyl)-6-isoquinolinyl]-4'-(trifluoromethyl)- [1,1'-biphenyl]-2-carboxamide. CAS Number: 186390-48-7. Molecular Formula: C26H22F3N5O. Formula Weight: 477.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 246 nm. SMILES: O=C(C1=C(C2=CC=C(C(F)(F)F)C=C2)C=CC=C1)NC3=CC=C4C(CCN(C4)CC5=NN=CN5)=C3. InChi Code: InChI=1S/C26H22F3N5O/c27-26(28,29)20-8-5-17(6-9-20)22-3-1-2-4-23(22)25(35)32-21-10-7-19-14-34(12-11-18(19)13-21)15-24-30-16-31-33-24/h1-10,13,16H,11-12,14-15H2,(H,32,35)(H,30,31,33). InChi Key: WNDIAFXQKOHFLV-UHFFFAOYSA-N.