CDN1163

CDN1163 is an allosteric activator of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 (SERCA2) that enhances calcium uptake in endoplasmic reticulum (ER) vesicles when used at concentrations ranging from 1 to 10 µM. It decreases peroxide-induced cell death in HEK293 cells. CDN1163 (50 mg/kg) increases calcium uptake in ER microsomes isolated from obese mouse liver. It decreases blood glucose levels, plasma and hepatic triglyceride levels, and plasma cholesterol and malondialdehyde (MDA) levels in obese mice. CDN1163 (50 mg/kg) restores SERCA activity, prevents gastrocnemius muscle loss and contractile dysfunction, and reduces mitochondrial production of reactive oxygen species (ROS) in the CuZnSOD-deficient (Sod-/-) mouse model of oxidative stress-related muscle atrophy and weakness. It also improves motor deficits in the initiation time (IT), stepping, and cylinder tests for akinesia in a rat model of Parkinson's disease induced by 6-OHDA (Cay-25330).Formal Name: 4-(1-methylethoxy)-N-(2-methyl-8-quinolinyl)-benzamide. CAS Number: 892711-75-0. Molecular Formula: C20H20N2O2. Formula Weight: 320.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 5 mg/ml. SMILES: CC(C=C1)=NC2=C1C=CC=C2NC(C3=CC=C(OC(C)C)C=C3)=O. InChi Code: InChI=1S/C20H20N2O2/c1-13(2)24-17-11-9-16(10-12-17)20(23)22-18-6-4-5-15-8-7-14(3)21-19(15)18/h4-13H,1-3H3,(H,22,23). InChi Key: GVGVYDCVFBGALZ-UHFFFAOYSA-N.