alpha-GalCer analog 8

alpha-Galactosylceramide analog 8 (alpha-GalCer analog 8) is a triazole derivative of alpha-galactosylceramide. It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with alpha-GalCer analog 8 at a concentration of 32 ng/ml. alpha-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic alpha-GalCer KRN 7000 (Cay-11208) in mouse splenocytes in vitro and in mouse serum following administration of a 1 µg per animal dose, indicating a Th2 response.Formal Name: (2S,3S,4R)-3,4-dihydroxy-2-(4-tetracosyl-1H-1,2,3-triazol-1-yl)octadecyl, alpha-D-galactopyranoside. CAS Number: 922727-14-8. Synonyms: alpha-Galactosylceramide analog 8. Molecular Formula: C50H97N3O8. Formula Weight: 868.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)([H])N2N=NC(CCCCCCCCCCCCCCCCCCCCCCCC)=C2. InChi Code: InChI=1S/C50H97N3O8/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-42-39-53(52-51-42)43(41-60-50-49(59)48(58)47(57)45(40-54)61-50)46(56)44(55)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h39,43-50,54-59H,3-38,40-41H2,1-2H3/t43-,44+,45+,46-,47-,48-,49+,50-/m0/s1. InChi Key: YLAIBGQPPXWHSD-MKADWPIHSA-N.