9-keto Fluprostenol

9-keto Fluprostenol is an analog of prostaglandin E2 (PGE2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2alpha and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. It is anticipated that this analog will have strong affinity for EP receptors and act as a PGE2 agonist.Formal Name: (5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-5-oxocyclopentyl]-5-heptenoic acid. CAS Number: 156406-33-6. Synonyms: Fluprostenol Prostaglandin E2. Molecular Formula: C23H27F3O6. Formula Weight: 456.5. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: Ethanol: Miscible, PBS (7.2): 10 mg/ml. lambdamax: 222, 277 nm. SMILES: O[C@H]1[C@H](/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2)[C@@H](C/C=C\CCCC(O)=O)C(C1)=O. InChi Code: InChI=1S/C23H27F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-19,21,27,29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,21-/m1/s1. InChi Key: WWMXHYUXIKWXSR-AAHOZRAYSA-N.