7,3',4'-Trihydroxyflavone

7,3',4'-Trihydroxyflavone is a flavonoid that has been found in A. julibrissin bark and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) and peroxynitrite radicals in cell-free assays (IC50s = 2.2 and 5.78 µM, respectively), as well as reduces total reactive oxygen species in rat kidney homogenates (IC50 = 3.9 µM). 7,3',4'-Trihydroxyflavone inhibits COX-1 (IC50 = 36.7 µM). It is active against M. tuberculosis (MIC = 50 µg/ml). It decreases mRNA expression of the osteoclastic marker genes encoding the calcitonin receptor, cathepsin K1 V-ATPase V0 subunit d2 (Atp6v0d2), and dendritic cell specific transmembrane protein (Dcstamp) in and inhibits RANKL-induced osteoclastic differentiation of mouse bone marrow-derived macrophages (BMDMs).Formal Name: 2-(3,4-dihydroxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one. CAS Number: 2150-11-0. Synonyms: 3',4',7-Trihydroxyflavone, 5-Deoxyluteolin. Molecular Formula: C15H10O5. Formula Weight: 270.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml. lambdamax: 238, 343 nm. SMILES: O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=C1C=CC(O)=C3. InChi Code: InChI=1S/C15H10O5/c16-9-2-3-10-12(18)7-14(20-15(10)6-9)8-1-4-11(17)13(19)5-8/h1-7,16-17,19H. InChi Key: PVFGJHYLIHMCQD-UHFFFAOYSA-N. Origin: Synthetic.