5alpha-Androstan-3beta-ol

5alpha-Androstan-3beta-ol is a steroidal androgen. It binds to the androgen receptor in a cell-free assay (IC50 = 1.7 µM) and activates the pregnane X receptor (PXR) in HepG2 cells in a reporter assay (EC50 = 0.8 µM). 5alpha-Androstan-3beta-ol also inhibits the androst-4-ene-3,17-dione hydroxylase activities of 16alpha- and 6beta-hydroxylase but not 16beta- or 7alpha-hydroxylase (IC50s = 70, 110, >150, and >150 µM, respectively). It decreases testis weight and sperm production in mice when administered at a dose of 30 mg/kg.CAS Number: 1224-92-6. Synonyms: NSC 50887. Molecular Formula: C19H32O. Formula Weight: 276.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble. SMILES: C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(CCC4)C. InChi Code: InChI=1S/C19H32O/c1-18-9-3-4-16(18)15-6-5-13-12-14(20)7-11-19(13,2)17(15)8-10-18/h13-17,20H,3-12H2,1-2H3/t13-,14-,15-,16-,17-,18-,19-/m0/s1. InChi Key: DJTOLSNIKJIDFF-LOVVWNRFSA-N.