4-hydroxy Estrone

4-hydroxy Estrone is a metabolite of the endogenous estrogen estrone (Cay-10006485). It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1B1, CYP1A2, and CYP1A1. 4-hydroxy Estrone (5 µM) induces nuclear translocation of phosphorylated p53 and is protective against glutamate-induced oxidative death in HT22 hippocampal neuronal cells. It reduces neurodegeneration induced by kainic acid in the rat hippocampus and improves working memory in the Y-maze in rats when administered at a dose of 10 µg/animal. 4-hydroxy Estrone also inhibits proliferation of MCF-7 and MDA-MB-231 breast cancer cells with IC50 values of 30 and 38 µM, respectively.Formal Name: 3,4-dihydroxy-estra-1,3,5(10)-trien-17-one. CAS Number: 3131-23-5. Synonyms: 4-hydroxy E1, 4-OHE1. Molecular Formula: C18H22O3. Formula Weight: 286.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Ethanol: slightly, sonicated. SMILES: C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C(O)=C4CC3. InChi Code: InChI=1S/C18H22O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,19,21H,2-3,5,7-9H2,1H3/t11-,12-,14+,18+/m1/s1. InChi Key: XQZVQQZZOVBNLU-QDTBLXIISA-N.