21-Deoxycortisol-d8

21-Deoxycortisol-d8 is intended for use as an internal standard for the quantification of 21-deoxycortisol (Cay-30873) by GC- or LC-MS. 21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal gland via 11-hydroxylation by 11beta-hydroxylase. Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations in CYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.Formal Name: 11,17-dihydroxy-pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8. CAS Number: 2479914-04-8. Synonyms: 21-Dehydrohydrocortisone-d8. Molecular Formula: C21H22D8O4. Formula Weight: 354.5. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 241 nm. SMILES: C[C@@]12[C@](CC[C@]2(O)C(C([2H])([2H])[2H])=O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)C. InChi Code: InChI=1S/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1/i1D3,4D2,6D2,10D. InChi Key: LCZBQMKVFQNSJR-ZERYXUNYSA-N.