20-HEPE

20-HEPE is a metabolite of eicosapentaenoic acid (EPA, Cay-90110, Cay-21908, Cay-90110.1) that is formed via omega-oxidation of EPA by cytochrome P450 (CYP) omega-oxidases, including human CYP4F3B. It activates peroxisome proliferator-activated receptor alpha (PPARalpha) in COS-7 cells expressing a luciferase reporter when used at a concentration of 10 µM. 20-HEPE also activates murine transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks antinociceptive activity in rats.Formal Name: 20-hydroxy-5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid. CAS Number: 116477-57-7. Molecular Formula: C20H30O3. Formula Weight: 318.5. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: miscible, DMSO: miscible, Ethanol: miscible, PBS (pH 7.2): 0.8 mg/ml. SMILES: OCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C20H30O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12-13,15,21H,2,5,8,11,14,16-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-,15-13-. InChi Key: PPMOWWAALQWWLJ-NUKMUHRASA-N.