2-Linoleoyl Glycerol

2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. The congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group is 2-linoleoyl glycerol (2-LG), and this compound also appears in vivo in conjunction with 2-AG. Although the intrinsic activity of 2-LG is low, it potentiates the activity of other endocannabinoids, including 2-AG. This "entourage" effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release.Formal Name: 9Z,12Z-octadecadienoic acid, 2-glyceryl ester. CAS Number: 3443-82-1. Synonyms: 2-LG. Molecular Formula: C21H38O4. Formula Weight: 354.5. Purity: >95% (as a 9:1 mixture of the 2-LG and 1-LG). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 140 µg/ml. SMILES: CCCCC/C=C\C/C=C\CCCCCCCC(=O)OC(CO)CO. InChi Code: InChI=1S/C21H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-20(18-22)19-23/h6-7,9-10,20,22-23H,2-5,8,11-19H2,1H3/b7-6-,10-9-. InChi Key: IEPGNWMPIFDNSD-HZJYTTRNSA-N. Side Chain Carbon Sum: 18:2.