1-Oleoyl Glycerol

1-Oleoyl glycerol is a monoacylglycerol containing oleic acid (Cay-90260) at the sn-1 position. 1-Oleoyl glycerol (10%), in a formulation with cyclosporin A (Cay-12088) in propylene glycol, enhances diffusion of cyclosporin A from the donor compartment of a Franz diffusion cell into the stratum corneum, epidermis, and dermis of porcine ear skin, as well as through the skin to the receptor compartment. Mixed micellar systems containing 1-oleoyl glycerol and bile salts increase the apparent permeability coefficient (Papp) and absorption rate of amphotericin B (Cay-11636) in perfused rat intestine in vivo. Formulations containing 1-oleoyl glycerol have been used as emulsifying agents, food additives, and absorption enhancers.Formal Name: 9Z-octadecenoic acid, 2,3-dihydroxypropyl ester. CAS Number: 111-03-5. Synonyms: 18:1-MG, MG(18:1), 1-Monoolein, 1-Oleoyl-rac-glycerol. Molecular Formula: C21H40O4. Formula Weight: 356.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: 50 mg/ml. SMILES: O=C(CCCCCCC/C=C\CCCCCCCC)OCC(O)CO. InChi Code: InChI=1S/C21H40O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h9-10,20,22-23H,2-8,11-19H2,1H3/b10-9-. InChi Key: RZRNAYUHWVFMIP-KTKRTIGZSA-N.