ZD 7288

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to native pacemaker currents in heart and neurons and modulate cardiac and neuronal excitability. Certain HCN channels also accentuate neuropathic pain. ZD 7288 is a potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively). Through its effects on HCN channels, ZD 7288 modulates the sinoatrial node and slows heart rate. In addition, ZD 7288 reduces neuropathic pain in several animal models.Formal Name: N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine, monohydrochloride. CAS Number: 133059-99-1. Synonyms: ICI-D 7288. Molecular Formula: C15H21N4 . Cl. Formula Weight: 292.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 241, 285 nm. SMILES: CCN(C1=NC(C)=[N+](C)C(NC)=C1)C2=CC=CC=C2.[Cl-]. InChi Code: InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15,/h6-11H,5H2,1-4H3,1H. InChi Key: DUWKUHWHTPRMAP-UHFFFAOYSA-N.