Z-FR-AMC (trifluoroacetate salt)

Z-FR-AMC is a fluorogenic substrate for cathepsin L. Upon enzymatic cleavage by cathepsin L, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify cathepsin L activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.Formal Name: N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide, trifluoroacetate salt. Synonyms: Z-FR-7-amino-4-Methylcoumarin, Z-Phe-Arg-AMC. Molecular Formula: C33H36N6O6 . XCF3COOH. Formula Weight: 612.7. Purity: >98%. Emission: 440-460 nm. Excitation: 340-360 nm. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 325 nm. SMILES: CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)=O)C=C1O4)=CC4=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C33H36N6O6.C2HF3O2/c1-21-17-29(40)45-28-19-24(14-15-25(21)28)37-30(41)26(13-8-16-36-32(34)35)38-31(42)27(18-22-9-4-2-5-10-22)39-33(43)44-20-23-11-6-3-7-12-23,3-2(4,5)1(6)7/h2-7,9-12,14-15,17,19,26-27H,8,13,16,18,20H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,34,35,36),(H,6,7)/t26-,27-,/m0./s1. InChi Key: AVPSADNFAQBJBZ-WMXJXTQLSA-N.