Z-DEVD-CMK (trifluoroacetate salt)

Z-DEVD-CMK is a protease inhibitor. It irreversibly inhibits recombinant caspase-3, cathepsin B, cathepsin L, cathepsin V, cathepsin F, and cathepsin S in enzyme assays but has no effect on these cathepsins in Jurkat T cells. Z-DEVD-CMK (3 mg/kg) improves endotoxin-induced myocardial dysfunction and reduces caspase-1, -3, and -8 activation and apoptosis in a rat model of endotoxin-induced myocardial dysfunction and heart apoptosis.Formal Name: N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide, trifluoroacetate salt. Synonyms: Z-Asp-Glu-Val-Asp-CMK. Molecular Formula: C27H35ClN4O12 . XCF3COOH. Formula Weight: 643.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 1 mg/ml. SMILES: O=C(OCC1=CC=CC=C1)N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(CCl)=O)CC(O)=O)=O)=O)CCC(O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C27H35ClN4O12.C2HF3O2/c1-14(2)23(26(42)30-17(10-21(36)37)19(33)12-28)32-24(40)16(8-9-20(34)35)29-25(41)18(11-22(38)39)31-27(43)44-13-15-6-4-3-5-7-15,3-2(4,5)1(6)7/h3-7,14,16-18,23H,8-13H2,1-2H3,(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,34,35)(H,36,37)(H,38,39),(H,6,7)/t16-,17-,18-,23-,/m0./s1. InChi Key: UBIFJNREVWXBMB-ILOSSIDHSA-N.