Yoda2 (potassium salt)

A Piezo1 agonist, induces calcium influx in HEK cells overexpressing mouse Piezo1 (EC50 = 150 nM), selective for Piezo1 over 30 other ion channels and receptors at 5 µM, induces smooth muscle relaxation in isolated and perfused mouse portal veins (EC50 = 1.2 µM), increases cortical area and thickness at 15 and 37% of the tibial bone length in combination with loading in 22-month-old female mice in a model of aging-induced loss of bone adaptation at 5 µmol/kg