YM-298198 (hydrochloride)

YM-298198 is a non-competitive antagonist of the metabotropic glutamate receptor type I (mGluR1, Ki = 19 nM). It is selective for mGluR1 over mGluR2-7 (IC50s = 0.016 and >10 µM, respectively). YM-298198 binds to rat cerebellum membranes (Ki = 20 nM). In vivo, YM-298198 (10 and 30 mg/kg, p.o.) increases nociceptive response latency in a mouse model of hyperalgesia induced by streptozotocin (Cay-13104) without affecting motor coordination in a rotarod test. YM-298198 also reduces reinstatement of drug-seeking behavior induced by cocaine priming in rats.Formal Name: 6-amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]benzimidazole-2-carboxamide, monohydrochloride. CAS Number: 1216398-09-2. Molecular Formula: C18H22N4OS . HCl. Formula Weight: 378.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25 mg/ml, DMSO:PBS (pH 7.2)(1:8): 0.11 m/gml. lambdamax: 220, 252 nm. SMILES: NC1=CC=C2C(N(C(C)=C(C(N(C)C3CCCCC3)=O)S4)C4=N2)=C1.Cl. InChi Code: InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18,/h8-10,13H,3-7,19H2,1-2H3,1H. InChi Key: WYTJVUVCSUWZTH-UHFFFAOYSA-N.