Zu "K04603" wurden 49 Artikel gefunden!
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(R,S)-3-HPG
Artikelnummer: Cay37479-10
(R,S)-3-HPG is a racemic mixture of the group I metabotropic glutamate receptor 1 (mGluR1) agonist (S)-3-hydroxyphenylglycine and its isomer (R)-3-hydroxyphenylglycine.Formal Name: alpha-amino-3-hydroxy-benzeneacetic acid. CAS Number: 31932-87-3. Synonyms: (R,S)-3-Hydroxyphenylglycine. Molecular Formula: C8H9NO3....
| Schlagworte: | (R,S)-3-Hydroxyphenylglycine, alpha-amino-3-hydroxy-benzeneacetic acid |
| Anwendung: | (S)-3-hydroxyphenylglycine / (R)-3-hydroxyphenylglycine racemic mixture |
| CAS | 31932-87-3 |
| MW: | 167.2 D |
ab 88,00 €
Human GRM1 (Glutamate Receptor, Metabotropic 1) ELISA Kit
Artikelnummer: ELK-ELK4926.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GRM1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GRM1. Next,...
| Schlagworte: | GRM1, GPRC1A, mGluR1, Metabotropic glutamate receptor 1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
(S)-3,5-DHPG
Artikelnummer: Cay14411-1
(S)-3,5-DHPG, known more commonly as DHPG, is an agonist of the group I metabotropic glutamate receptors (mGluRs), binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors. The (S)-enantiomer is about ten times more potent than the (R)-enantiomer. (S)-3,5-DHPG is...
| Schlagworte: | (S)-3,5-Dihydroxyphenylglycine, (alphaS)-amino-3,5-dihydroxy-benzeneacetic acid |
| Anwendung: | mGluR1 / mGluR5a agonist |
| CAS | 162870-29-3 |
| MW: | 183.2 D |
ab 77,00 €
Ro 67-7476
Artikelnummer: Cay11993-10
Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 µM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 µM. Ro 67-7476 increases the...
| Schlagworte: | 2S-(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine |
| Anwendung: | Positive allosteric mGlu1 receptor modulator |
| CAS | 298690-60-5 |
| MW: | 319.4 D |
ab 43,00 €
CPCCOEt
Artikelnummer: Cay21486-1
CPCCOEt is a low affinity, selective, non-competitive antagonist of the metabotropic glutamate receptor subtype mGluR1b. It has been shown to inhibit glutamate-induced increases in intracellular calcium at human mGluR1b with an IC50 value of 6.5 µM while having no agonist or antagonist activity at mGluR2, -4a, -5a,...
| Schlagworte: | 7,7a-dihydro-7-(hydroxyimino)-benzo[b]cyclopropa[e]pyran-1a(1H)-carboxylic acid, ethyl ester |
| Anwendung: | Low affinity, selective, non-competitive mGluR1b antagonist |
| CAS | 179067-99-3 |
| MW: | 247.3 D |
ab 52,00 €
(S)-MCPG
Artikelnummer: Cay21450-10
(S)-MCPG is an antagonist of metabotropic glutamate receptors (mGluRs) and the active component of (±)-MCPG, which is selective for Group I and Group II mGluRs. (S)-MCPG inhibits motoneuron depolarization induced by 1-amino-1,3-dicarboxycyclopentane (ACPD) in neonatal rat spinal cord in vitro and ACPD-induced...
| Schlagworte: | (+)-MCPG, (+)-alpha-methyl-4-Carboxyphenylglycine, (S)-alpha-methyl-4-Carboxyphenylglycine,... |
| Anwendung: | Non-selective group I/group II metabotropic glutamate receptor antagonist |
| CAS | 150145-89-4 |
| MW: | 209.2 D |
ab 89,00 €
Anti-mGluR1a
Artikelnummer: 600-401-D75
Anti-mGluR1a antibodies are affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody. This antibody is directed against rat mGluR1a. Reactivity is expected from mouse. Cross reactivity from other...
| Schlagworte: | Anti-Grm1, Anti-mGluR1, Anti-Gprc1a, Anti-Metabotropic glutamate receptor 1 |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | rat, mouse |
684,00 €
A-841720
Artikelnummer: Cay21807-1
A-841720 is a noncompetitive antagonist of the group 1 metabotropic glutamate receptor mGluR1 with an IC50 value of 10.7 nM for inhibition of L-glutamate-induced calcium release in 1321 N1 cells. It is selective for mGluR1 over mGluR5 (IC50 = 343 nM) as well as mGluR2, mGluR4, and mGluR7, where it does not inhibit...
| Schlagworte: | 9-(dimethylamino)-3-(hexahydro-1H-azepin-1-yl)-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one |
| Anwendung: | Noncompetitive mGluR1 antagonist |
| CAS | 869802-58-4 |
| MW: | 343.5 D |
ab 43,00 €
ACPT-II
Artikelnummer: Cay78020-1
ACPT-II is a general competitive antagonist of metabotropic glutamate (mGlu) receptors. The KB values for mGlu1a, mGlu2, and mGlu4a receptors are 115, 88, and 77 µM, respectively. It binds to the large extracellular domain called a Venus flytrap module, where agonists bind. ACPT-II is a stereoisomer of the group III...
| Schlagworte: | 4-amino-1alpha,2alpha,4beta-cyclopentanetricarboxylic acid |
| Anwendung: | Competitive metabotropic glutamate (mGlu) receptor antagonist |
| CAS | 195209-04-2 |
| MW: | 217.2 D |
ab 60,00 €
YM-298198 (hydrochloride)
Artikelnummer: Cay22925-1
YM-298198 is a non-competitive antagonist of the metabotropic glutamate receptor type I (mGluR1, Ki = 19 nM). It is selective for mGluR1 over mGluR2-7 (IC50s = 0.016 and >10 µM, respectively). YM-298198 binds to rat cerebellum membranes (Ki = 20 nM). In vivo, YM-298198 (10 and 30 mg/kg, p.o.) increases nociceptive...
| Schlagworte: | 6-amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]benzimidazole-2-carboxamide, monohydrochloride |
| Anwendung: | mGluR1 antagonist |
| CAS | 1216398-09-2 |
| MW: | 378.9 D |
ab 50,00 €
VU0483605
Artikelnummer: Cay16941-1
Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced...
| Schlagworte: | 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide |
| Anwendung: | Selective positive mGluR1 allosteric modulator |
| CAS | 1623101-11-0 |
| MW: | 446.7 D |
ab 66,00 €
Anti-GRM1
Artikelnummer: E-AB-63478.120
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of...
| Schlagworte: | Anti-GRM1, Anti-mGluR1, Anti-GPRC1A, Anti-Metabotropic glutamate receptor 1, GRM1 Polyclonal Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | rat |
ab 198,00 €