XL-784 free base

Description: XL-784 free base is a selective inhibitor of matrix metalloproteinases (MMP) with IC50 values of ~1900, 0.81, 120, 10.8, 18, and 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, and MMP-13, respectively. Target: Others. Smiles: S(=O)(=O)(N1C(C(NO)=O)CN(C(OCCOC)=O)CC1)C2=CC(F)=C(OC3=CC=C(Cl)C=C3)C(F)=C2. References: Williams JM, et al. Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy. Am J Physiol Renal Physiol. 2011 Apr,300(4):F983-98.