WAY-100635 (maleate)

WAY-100635 is a potent, silent antagonist of serotonin 5-HT1A receptors with an IC50 value of 2.2 nM (Ki = 0.8 nM) for inhibiting 5-HT1A receptors in rat hippocampal membranes. Because it displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes, WAY-100635 is classically used to examine the distribution and function of 5-HT1A receptors. However, WAY-100635 has also been shown to exhibit agonist activity at dopamine D4 receptors (Kd = 2.4 nM).Formal Name: N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide, 2Z-butenedioate. CAS Number: 1092679-51-0. Molecular Formula: C25H34N4O2 . C4H4O4. Formula Weight: 538.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 15 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 271 nm. SMILES: O=C(C1CCCCC1)N(C2=NC=CC=C2)CCN(CC3)CCN3C4=CC=CC=C4OC.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C25H34N4O2.C4H4O4/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21,5-3(6)1-2-4(7)8/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: XIGAHNVCEFUYOV-BTJKTKAUSA-N.