VUF10460

VUF10460 is a histamine H4 receptor agonist (Kis = 5.01 and 14.13 nM for the human and rat receptors, respectively). It is selective for the rat histamine H4 receptor over the rat histamine H3 receptor (Kis = 34.67 and 1,778.28 nM, respectively). VUF10460 (10 mg/kg) potentiates the formation of HCl-induced ulcers in the rat gastric mucosa, an effect that is not blocked by the histamine H4 receptor antagonist JNJ-7777120 (Cay-10011925).Formal Name: 4-(4-methyl-1-piperazinyl)-6-phenyl-2-pyrimidinamine. CAS Number: 1028327-66-3. Molecular Formula: C15H19N5. Formula Weight: 269.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100mg/mL. lambdamax: 245, 316 nm. SMILES: CN(CC1)CCN1C2=CC(C3=CC=CC=C3)=NC(N)=N2. InChi Code: InChI=1S/C15H19N5/c1-19-7-9-20(10-8-19)14-11-13(17-15(16)18-14)12-5-3-2-4-6-12/h2-6,11H,7-10H2,1H3,(H2,16,17,18). InChi Key: NIJGWJIOMPHDBP-UHFFFAOYSA-N.