VU0360172 (hydrochloride)

VU036172 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5, Ki = 195 nM). It is selective for mGluR5 over mGluR1, mGluR3, and mGluR4 at 10 µM. VU036172 (20 and 50 µM) prevents TNF-alpha and nitric oxide (NO) production by IFN-gamma- or LPS-stimulated BV-2 and primary microglial cells. It reduces the expression of inducible nitric oxide synthase (iNOS) and increases the expression of Ym1 and arginase 1 in LPS-stimulated BV-2 cells when used at a concentration of 20 µM. VU036172 (50 mg/kg) reduces the size of cortical lesions, prevents neuronal degeneration, and improves sensorimotor deficits in the beam walk test in a mouse model of traumatic brain injury (TBI), indicating improved recovery of motor function.Formal Name: N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide, monohydrochloride. CAS Number: 1309976-62-2. Molecular Formula: C18H15FN2O . HCl. Formula Weight: 330.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 308 nm. SMILES: O=C(NC1CCC1)C2=CC=C(C#CC3=CC(F)=CC=C3)N=C2.Cl. InChi Code: InChI=1S/C18H15FN2O.ClH/c19-15-4-1-3-13(11-15)7-9-16-10-8-14(12-20-16)18(22)21-17-5-2-6-17,/h1,3-4,8,10-12,17H,2,5-6H2,(H,21,22),1H. InChi Key: NBGAPTWZQXSEAA-UHFFFAOYSA-N.