Vipadenant

Vipadenant is a selective adenosine 2A (A2A) receptor antagonist with Ki values of 1.3, 68, 63, and 1,005 nM for A2A, A1, A2B, and A3 receptors, respectively, in a radioligand binding assay. It acts as a functional antagonist of human recombinant A2A (KA = 0.58 nM) in a calcium mobilization-based FLIPR assay. Vipadenant also reverses haloperidol-induced hypolocomotion in mice and rats.Formal Name: 3-[(4-amino-3-methylphenyl)methyl]-7-(2-furanyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine. CAS Number: 442908-10-3. Synonyms: BIIB-014. Molecular Formula: C16H15N7O. Formula Weight: 321.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 43 mg/mL. lambdamax: 231, 301, 349 nm. SMILES: NC1=NC(C2=CC=CO2)=C3C(N(CC4=CC=C(N)C(C)=C4)N=N3)=N1. InChi Code: InChI=1S/C16H15N7O/c1-9-7-10(4-5-11(9)17)8-23-15-14(21-22-23)13(19-16(18)20-15)12-3-2-6-24-12/h2-7H,8,17H2,1H3,(H2,18,19,20). InChi Key: HQSBCDPYXDGTCL-UHFFFAOYSA-N.