Vincristine (sulfate)

Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization. Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein. Its effectiveness in blocking the proliferation of cancer cells is affected by overexpression of P-glycoprotein.Formal Name: 22-oxo-vincaleukoblastine sulfate. CAS Number: 2068-78-2. Synonyms: Kyocristine, Lilly 37231, Leurocristine, Novopharm, NSC 67574, Oncovin, VCR. Molecular Formula: C46H56N4O10 . H2SO4. Formula Weight: 923.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 5 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 221, 259, 296 nm. SMILES: CC[C@]1(O)C[C@@](C[N@@](CC2)C1)([H])C[C@](C(OC)=O)(C3=C(OC)C=C(N(C)[C@]4([H])[C@@]56[C@](N7CC6)([H])[C@](C=CC7)(CC)[C@@H](OC(C)=O)[C@]4(O)C(OC)=O)C5=C3)C8=C2C(C=CC=C9)=C9N8.O=S(O)(O)=O. InChi Code: InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6,1-5(2,3)4/h9-13,15,20-21. InChi Key: AQTQHPDCURKLKT-PNYVAJAMSA-N. Origin: Plant/Vinca rosea.