VER-155008

VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70, IC50 = 0.5 µM) that is selective over Hsp90. It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 µM) and glucose-regulated protein 78 (Grp78, KD = 80 nM). VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death. It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors. VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells.Formal Name: 5'-O-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine. CAS Number: 1134156-31-2. Molecular Formula: C25H23Cl2N7O4. Formula Weight: 556.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml. lambdamax: 216, 275 nm. SMILES: O[C@H]1[C@@H](O)[C@H](N2C(NCC3=CC=C(Cl)C(Cl)=C3)=NC4=C2N=CN=C4N)O[C@@H]1COCC5=CC=C(C#N)C=C5. InChi Code: InChI=1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1. InChi Key: ZXGGCBQORXDVTE-UMCMBGNQSA-N.