VEGFR2 Kinase Inhibitor IV

VEGFR2 kinase inhibitor IV is an inhibitor of VEGFR2 (IC50 = 19 nM). It is greater than 100-fold selective for VEGFR2 over FGFR1 and Src but only 1.8-, 10-, and 10-fold selective over PDGFRbeta, FLT1, and FLT2, respectively. VEGFR2 kinase inhibitor IV inhibits mitogenesis in human umbilical vein endothelial cells (HUVECs, IC50 = 387 nM). It also reduces VEGF-induced increases in neuroglobin levels in primary mouse cerebrocortical neurons when used at a concentration of 20 nM. SMILES: COC1=CC=C(C=C1)C2=CN3N=CC(C4=CSC=C4)=C3N=C2. InChi Code: InChI=1S/C17H13N3OS/c1-21-15-4-2-12(3-5-15)14-8-18-17-16(9-19-20(17)10-14)13-6-7-22-11-13/h2-11H,1H3. InChi Key: HBWLNACPIFKNIP-UHFFFAOYSA-N