(+)-Valencene

(+)-Valencene is a sesquiterpene that has been found in C. sativa and is an aromatic component of orange essence oil. (+)-Valencene (50 µM) induces heme oxgenase-1 (HO-1) expression in macrophages and inhibits the expression of inducible nitric oxide synthase (iNOS), the production of nitric oxide (NO), and the release of high-mobility group box-1 (HMGB1) in RAW 264.7 cells stimulated with LPS. It also increases the survival rate in a mouse model of sepsis induced by cecal ligation and puncture. (+)-Valencene has been used in the synthesis of nootkatone (Cay-24910).Formal Name: (1R,7R,8aS)-1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)-naphthalene. CAS Number: 4630-07-3. Synonyms: NSC 148969. Molecular Formula: C15H24. Formula Weight: 204.4. Purity: >75%. Formulation: (Request formulation change), A liquid. Solubility: Water: Slightly Soluble. SMILES: CC([C@@H]1CCC2=CCC[C@@H](C)[C@]2(C)C1)=C. InChi Code: InChI=1S/C15H24/c1-11(2)13-8-9-14-7-5-6-12(3)15(14,4)10-13/h7,12-13H,1,5-6,8-10H2,2-4H3/t12-,13-,15+/m1/s1. InChi Key: QEBNYNLSCGVZOH-NFAWXSAZSA-N.