UPGL00004

A GAC inhibitor (IC50 = 29 nM), reduces the proliferation of MDA-MB-231, Hs 578T, and TSE cells (IC50s = 70, 129, and 262 nM, respectively), inhibits replication of SARS-CoV-2 and HCoV-OC43 in Vero and primary HBECs, respectively, at 0.1 µM. Formulation: A solid. InChI: InChI=1S/C25H26N8O2S2/c34-20(15-17-7-3-1-4-8-17)27-23-30-29-22(36-23)26-19-11-13-33(14-12-19)25-32-31-24(37-25)28-21(35)16-18-9-5-2-6-10-18/h1-10,19H,11-16H2,(H,26,29)(H,27,30,34)(H,28,31,35). InChIKey: MRYCNTHLPRENBA-UHFFFAOYSA-N. SMILES: O=C(CC1=CC=CC=C1)NC(S2)=NN=C2NC3CCN(C4=NN=C(NC(CC5=CC=CC=C5)=O)S4)CC3