Upacicalcet

Description: Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-sensitive receptors, thereby lowering blood levels of PTH.Upacicalcet is an orthosteric modulator of calcium-sensitive receptors and prevents adenine-induced secondary vascular calcification and bone disease in a rat model of adenine-induced secondary hyperparathyroidism. Target: Calcium Channel. Smiles: N(C(NC[C@@H](C(O)=O)N)=O)C1=CC(S(=O)(=O)O)=CC(Cl)=C1C. References: Hoy SM. Upacicalcet: First Approval. Drugs. 2021,81(13):1593-1596.