Umeclidinium (bromide)

Umeclidinium is an antagonist of muscarinic acetylcholine receptors (Kis = 0.05-0.16 nM for M1-M5 human recombinant receptors). It inhibits acetylcholine-induced activation of recombinant M3 receptors in CHO cell membranes (IC50 = 50 = 10 µM) and bronchoconstriction in mice when administered intranasally (ED50 = 0.02 µg). Formulations containing umeclidinium have been used in the treatment of chronic obstructive pulmonary disease (COPD).Formal Name: 4-(hydroxydiphenylmethyl)-1-[2-(phenylmethoxy)ethyl]-1-azoniabicyclo[2.2.2]octane, monobromide. CAS Number: 869113-09-7. Synonyms: GSK573719. Molecular Formula: C29H34NO2 . Br. Formula Weight: 508.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 0.14 mg/ml. lambdamax: 257 nm. SMILES: OC(C1=CC=CC=C1)(C2=CC=CC=C2)C34CC[N+](CC4)(CCOCC5=CC=CC=C5)CC3.[Br-]. InChi Code: InChI=1S/C29H34NO2.BrH/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25,/h1-15,31H,16-24H2,1H/q+1,/p-1. InChi Key: PEJHHXHHNGORMP-UHFFFAOYSA-M.